Tuesday, January 31, 2012

12 Reasons to Switch to DNA2.0 in 2012

Make 2012 Your Breakthrough Year : 12 Reasons to Switch to DNA2.0 in 2012


Break through with the help of DNA2.0 in 2012. This is the one resolution that will help you succeed with the all the others on your research list.

Menlo Park, Calif. (PRWEB) January 20, 2012

Achieve your most import resolution for 2012—to work smarter, not harder— by letting DNA2.0 bioengineering solutions save you time and money and achieve better results. Whether you are looking to make the upgrade from cloning to synthesis, want the peace of mind that comes with guaranteed expression or need a variant library to engineer protein function, it’s time to make the leap to DNA2.0.

[caption id="attachment_77" align="aligncenter" width="377"]12 Reasons to Switch to DNA2.0 in 2012 12 Reasons to Switch to DNA2.0 in 2012[/caption]

While you consider all the reasons to make the switch, check out the ever-growing list of leading scientists that have already had their breakthroughs with a little help from DNA2.0: https://www.dna20.com/successstories.php

1. Save Time—Don’t let the competition get ahead of you

Every day saved in the process of accessing your genetic constructs is a day gained on the competition. First to publish is also first to get the next grant. First to patent is also first to get the next VC round. DNA2.0 Rush Service offers custom synthesized genes up to 1kb in size guaranteed to ship in 5 business days—the fastest available. Our regular service is an industry-leading 8-10 day turnaround.

2. Focus on Innovation—Our approach is light years ahead of any other provider

You’re not in the lab to clone genes, you’re there to do science. Don't spend months fiddling with expression vectors, tags, culture conditions and temperatures. With maximal protein expression powered by our patentedGeneGPS™ algorithms, you can focus on the critical experiments that advance your research.

3. Reliable, High-Protein Expression Yields with GeneGPS

No point in getting a synthetic gene if it does not express your protein. Breakthrough research by DNA2.0 has identified the design principles by which codons are used to maximize protein expression. The peer-reviewed, published research, funded by the National Science Foundation, has produced a set of design algorithms that reliably offers maximized expression yields for heterologous protein expression.

4. Instantly Scale Up or Down

You need 1,000 genes today and then nothing for 12 months? You need a simple gene or multisite combinatorial library? How about synthesizing an entire genome? No problem. DNA2.0 handles large and small orders with equal efficiency. No need to scale your in-house molecular biology resources to fit the ups and down of your research. And DNA2.0 is the industry leader at synthesizing long and/or difficult sequences, from 200 kb and up!

5. Answers to Protein Questions

When your research needs to go beyond the everyday, DNA2.0 has the expertise to take you to the next level. UtilizeProtein Variant Libraries for structure-function relationship analysis, or modifying the activities of proteins or DNA regulatory regions. Harness the power of synthetic biology to create Antibody Libraries with diversity in one or more CDRs. DNA2.0 makes libraries in several formats to meet different research needs. Libraries are delivered ready for screening to identify variants with altered function.

6. Improve on Nature

Any sequence you can imagine is available with synthetic genes. DNA2.0's rapid and efficient custom gene synthesis allows you to redesign entire gene sequences to maximize the likelihood of high protein expression, easy genetic manipulation, minimal promoter leakiness and convenient protein purification.

7. Avoid Mistakes

Why risk losing time on mistakes that could happen in-house? Why go with bargain synthesis providers that can’t guarantee strong protein expression? When you ask DNA2.0 to handle your gene synthesis, we make sure you get the genes you need, every time, on time. Never again curse the Gods of PCR.

8. Get to the Point—Engineer the Right Protein

Find the protein activity you need with ProteinGPS™—the protein engineering system that quickly and efficiently designs proteins with improved characteristics. ProteinGPS relies on identifying key amino acid substitutions through bioinformatics-based mining of available sequence space and combining such substitutions in an information maximized variant dataset (usually less than 100 unique gene variants).  At that scale determining the activity for the commercially relevant function in an indicative assay can be readily performed. By optimizing directly for function in the final application, you can save years of time and millions of dollars.

9. Talk to a Scientist

Instant access to expertise in the fields of protein expression, gene synthesis and the voodoo of cloning. We at DNA2.0 have published extensively in the area of technology development and new applications of synthetic biology. DNA2.0 is a resource and research partner for accurate and innovative, useful solutions. Want an actual person to answer when you have a question? Let our Customer Service Ph.D.s be an extension of your lab.

10. Airtight IP Protection

DNA2.0 understands the value of your intellectual property. DNA2.0 never outsources your gene synthesis orders to facilities in countries with lax IP protection. DNA2.0 synthesizes all orders at our state-of-the-art facility in Menlo Park, California. You always own full rights to your material.

11. Groundbreaking Gene Design and Assembly Tool—Free!

What could be easier than using DNA2.0‘s patented drag-and-drop sequence functionality to design genes de novo? DNA2.0's free Gene Designer enables you to put your imagination to work and guides you through every step, from inspiration to synthesized gene. Simplify your work by utilizing preassembled and validated BIOFAB parts from the Gene Designer Toolbox. With a tool like Gene Designer doing the heavy lifting, you spend more time focused on your research.

12. Freedom of Expression with the pJexpress family of vectors

DNA2.0 synthetic genes are available in vectors that are immediately usable for bacterial, mammalian and yeast protein expression. Cloning into these vectors is quickly completed in-house and the constructs are provided without IP restrictions.

Break through with the help of DNA2.0 in 2012. This is the one resolution that will help you succeed with the all the others on your research list. Call or email today for a quote: info(at)DNA20(dot)com or toll free at +1 877 DNA TOGO.

About DNA2.0
DNA2.0 is the leading bioengineering solutions provider. Founded in 2003, DNA2.0 offers an integrated pipeline of solutions for the research community, including gene design, optimization, synthesis and cloning, as well as platforms for protein and strain engineering. It is the fastest provider of synthetic genes—based in the US with a global customer base encompassing academia, government and the pharmaceutical, chemical, agricultural and biotechnology industries. DNA2.0 is by far the most published synthetic gene vendor, providing expert support to and collaboration with scientists. DNA2.0 explores novel applications for synthetic genes and is exploiting the synergy between highly efficient gene design and synthesis processes and new protein optimization technologies. DNA2.0’s tools and solutions are fueling the transformation of biology from a discovery science to an engineering discipline. The company is privately held and is headquartered in Menlo Park, Calif. For more information, please visit http://www.DNA20.com.

Source: PRWeb - http://www.prweb.com/releases/2012/1/prweb9112631.htm

DNA2.0 Integrates Synthetic Biology Open Language

DNA2.0 Integrates Synthetic Biology Open Language (SBOL) Into Gene Designer


DNA2.0 announces the integration of the first standardized information exchange framework for synthetic biology into the company's breakthrough gene design and assembly application.


Menlo Park, CA (PRWEB) December 14, 2011

DNA2.0 the leading provider of bioengineering solutions, today announced the integration of the Synthetic Biology Open Language (SBOL) into the company’s groundbreaking gene design and assembly tool, Gene Designer. SBOL is a synthetic biology standard exchange format that allows scientists to share, store, explore and publish genetic elements created through computer design. This newly-released language forms the basis for Gene Designer’s integration of genetic parts from BIOFAB and enables a new feature in the application called Diagram. Diagram provides a clean visualization interface of designed sequences and eases scientific collaboration by enabling graphic exports of sequences.

[caption id="attachment_73" align="aligncenter" width="400"]DNA2.0 Integrates Synthetic Biology Open Language DNA2.0 Integrates Synthetic Biology Open Language[/caption]

Biological design tools such as Gene Designer are playing a key role in the evolution of biology from a discovery-based science to an engineering discipline, where individuals from diverse technical backgrounds interact with genetic information. In order to make these tools more efficient between scientists and across disciplines, it is critical that companies, labs and individual scientists are able to share and store hierarchical sequence information in a format that is consistent, stable and accurately annotated. SBOL is the first such standardized information exchange framework created specifically for bioengineering. SBOL's development began in 2008 with a small grant from Microsoft, and since then it has grown to include a wide consortium of individuals, public institutions and commercial enterprises both in the US and Europe. SBOL version 1.0 was released in October, 2011.

“Only through the integration of standardized, open source tools and datasets with the emerging synthetic biology industry will we be able to build the framework for the next manufacturing revolution: bioengineering. I’m excited to see the early adoption of SBOL and BIOFAB by DNA2.0 with their Gene Designer program. The ability to create, share and utilize standardized high quality biological building blocks is key to the advancement of synthetic biology” said BIOFAB Director Drew Endy, of Stanford Bioengineering and the BioBricks Foundation.”

DNA2.0 developed the free software application, Gene Designer, to help scientists create genes with a graphically rich computer-aided design tool that enables bioengineers to easily manipulate and visualize DNA elements such as promoters, terminators, fusion tags and vector components. Gene Designer’s SBOL compliance, along with the new Diagram feature, makes it easier than ever for scientists to share accurate, consistent sequence data across any enterprise. DNA2.0 is committed to ensure full SBOL compatibility as the field of bioengineering and synthetic biology grows.

“The growth of the bioengineering industry enabled by synthetic biology and gene synthesis requires a new software platform for interacting with designed genetic information,” said Alan Villalobos, Director of Synthetic Biology at DNA2.0. “We are proud to be part of the SBOL development team that is building the first industrial framework for bioengineering.”

About DNA2.0
DNA2.0 is the leading bioengineering solutions provider. Founded in 2003, DNA2.0 offers an integrated pipeline of solutions for the research community, including gene design, optimization, synthesis and cloning, as well as platforms for protein and strain engineering. It is the fastest provider of synthetic genes—based in the US with a global customer base encompassing academia, government and the pharmaceutical, chemical, agricultural and biotechnology industries. DNA2.0 is by far the most published synthetic gene vendor, providing expert support to and collaboration with scientists. DNA2.0 explores novel applications for synthetic genes and is exploiting the synergy between highly efficient gene design and synthesis processes and new protein optimization technologies. DNA2.0’s tools and solutions are fueling the transformation of biology from a discovery science to an engineering discipline. The company is privately held and is headquartered in Menlo Park, Calif. For more information, please visit http://www.DNA20.com.

 

Source : PRWeb - http://www.prweb.com/releases/2011/12/prweb9023333.htm

Development of DNA Synthesis Technology

DuPont and OligoCo to Collaborate on Development of DNA Synthesis Technology


New Technology Will Dramatically Increase Capabilities to Utilize Genetic Information to Help Feed the World


DES MOINES, Iowa, and BOTHELL, Wash. (PRWEB) January 30, 2012

DuPont and OligoCo have entered into a collaboration to develop new technology that could enable the intense use of synthetic biology to help feed a growing global population. The efficient production of long, high-quality DNA segments known as oligonucleotides is essential to reliably transcribe genetic information into full length genes, and accelerate the pace of discovery and development of improved crop products.

[caption id="attachment_71" align="aligncenter" width="400"]Development of DNA Synthesis Technology Development of DNA Synthesis Technology[/caption]

Under the agreement, DuPont business Pioneer Hi-Bred will collaborate with OligoCo to develop a next generation oligonucleotide synthesizer. Pioneer will leverage the new technology in its customer-focused agriculture biotech research programs by combining it with its proprietary gene shuffling technology as well as other synthetic biology tools to increase throughput and probability of success in early discovery.

“Harnessing the most advanced tools in plant molecular genetics is essential to developing crops with improved traits,” said John Bedbrook, vice president, DuPont Agricultural Biotechnology. “Our collaboration with OligoCo enables us to further develop and access cutting-edge technology that helps us improve crop performance faster and more efficiently.”

Oligonucleotides are short DNA sequences which are used in a number of applications to transcribe the genetic code. Today’s oligonucleotide synthesizers allow scientists to produce and assemble DNA sequences rapidly, but cost and quality of oligonucleotides produced vary significantly, preventing the broad deployment of synthetic biology techniques. Pioneer’s requirements for high-quality, product-enabling discovery tools and OligoCo’s proprietary technology and commitment to quality, along with the resources from both companies will be brought together to develop the next generation oligonucleotide synthesizer.

“OligoCo is excited to work with Pioneer in the development of the next generation oligonucleotide synthesis technology,” said John Richards, president, OligoCo. “In combination with our other collaborators, our goal is to introduce a novel synthesis platform that provides high throughput, low error rates and low cost, all of which are important enablers for synthetic biology.”

OligoCo, formerly Blue Heron Biotechnology and a leader in gene synthesis, has significant experience in oligonucleotide synthesis.

Pioneer Hi-Bred, a DuPont business headquartered in Des Moines, Iowa, is the world’s leading developer and supplier of advanced plant genetics, providing high-quality seeds to farmers in more than 90 countries. Pioneer provides agronomic support and services to help increase farmer productivity and profitability and strives to develop sustainable agricultural systems for people everywhere. Science with Service Delivering Success™.

DuPont (NYSE: DD) has been bringing world-class science and engineering to the global marketplace in the form of innovative products, materials, and services since 1802. The company believes that by collaborating with customers, governments, NGOs, and thought leaders we can help find solutions to such global challenges as providing enough healthy food for people everywhere, decreasing dependence on fossil fuels, and protecting life and the environment. For additional information about DuPont and its commitment to inclusive innovation, please visit http://www.dupont.com.

 

Source : PRWeb - http://www.prweb.com/releases/2012/1/prweb9149110.htm